However, people who eat seafood one to four times a week are less likely to die of heart disease. High doses of omega-3s can reduce levels of triglycerides.Omega-3 supplements may help relieve symptoms of rheumatoid arthritis.Omega-3 supplements have not been convincingly shown to slow the progression of the eye disease age-related macular degeneration.For most other conditions for which omega-3 supplements have been studied, the evidence is inconclusive or doesn’t indicate that omega-3s are beneficial.What do we know about the safety of omega-3 supplements? Omega-3s usually produce only mild side effects, if any.There’s conflicting evidence on whether omega-3s might influence the risk of prostate cancer.If you’re taking medicine that affects blood clotting or if you’re allergic to fish or shellfish, consult your health care provider before taking omega-3 supplements.A 2011 evaluation of 17 studies indicated that people who eat seafood (fish and shellfish) one to four times a week are less likely to die of heart disease than those who rarely or never eat seafood.A 2018 analysis of 10 major omega-3 supplementation studies (77,917 total participants, all at high risk of heart disease), each of which involved at least 500 participants and a treatment duration of at least a year, found no evidence that omega-3s could reduce the risk of fatal or nonfatal coronary heart disease.Government’s Agency for Healthcare Research and Quality (AHRQ) did a comprehensive evaluation of 98 studies of omega-3s and heart disease, including both diet and supplementation studies.
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